Research Award Details

2011 - POSNA/OREF Research Grant

The Embryological Basis of Congenital Femoral and Tibial Deficiency

Grant Recipient: Sevan Hopyan, MD

Hospital for Sick Children, Toronto, ON Canada
Presentations & Publications:
Presentations: 1. Iroquois genes regulate limb pattern formation. 12th International conference on limb development and regeneration, Mt. Tremblant, Canada, 2012. 2. Developmental and genetic aetiology of tibial hemimelia in mouse and human. POSNA, Toronto, 2013 Publications: 1. Li D, Sakuma R, Vakili NA, Mo R, Puviindran V, Deimling S, Zhang X, Hopyan S, Hui C- c. Formation of proximal and anterior limb skeleton requires early function of Irx3 and Irx5 and is negatively regulated by Shh signaling. Developmental Cell 2. Zhulyn O, Li, D, Deimling S, Vakili NA, Mo R, Puviindran V, M-M Chen, P-T Chuang, Hopyan S, Hui C-c. A switch from low to high Shh activity regulates establishment of limb progenitors and signaling centers. Developmental Cell (2014)
Further Funding:
An application to CIHR for a 5 year grant is currently under review. This application received a very high score in the last round and stands strong in particular because of the two recent publications in Developmental Cell. We shall have an answer in June. 
Additional Information:
The POSNA research grant was a very useful boost to my lab at a very vulnerable time. It is a pleasure to offer the following responses