Research Recipients

Research Award Details

2017 - Angela S.M. Kuo Memorial Award

A Bioinspired Approach to Large Pediatric Osteochandral Injuries

Grant Recipient: Patrick Whitlock, MD

Co-Investigators: James Lin, PhD

Institution:: Cincinnati Children's Hospital Medical Center

Presentations & Publications:: Presentations
Gruber, S.M.S., Murab, S., Ghosh, P., Lin, C-Y., Whitlock, P.W. (2020). In vivo evaluation of a 3-d printed inductive scaffold for the treatment of porcine osteochondral defects. E-poster in preparation for submission to POSNA 2021 as requested.
Gruber, S.M.S., Murab, S., Whitlock, P.W., Lin, C-Y. (2020, February). 3D Printed Synthetic and Decellularized Matrix Scaffolds for Treatment of Osteochondral Injury In Vitro and In Vivo. Podium session to be presented at annual Orthopaedic Research Society (ORS) Meeting, Phoenix, Arizona.
Gruber, S.M.S., Murab, S., Whitlock, P.W., Lin, C-Y. (2019, December). Assessment of a Universal Printing Technology for Biphasic Scaffolds Containing Decellularized Bone and Cartilage Matrix. Podium session to be presented at annual Tissue Engineering and Regenerative Medicine International Society (TERMIS) meeting, Orlando, Florida.
Gruber, S.M.S., Murab, S., Ghosh, P., Whitlock, P.W., Lin, C-Y. (2019, October). A Biofabrication Technique to 3D-print Scaffolds Containing Decellularized Tissue Matrix. Poster session presented at annual Biomedical Engineering Society (BMES) meeting, Philadelphia, Pennsylvania.
Gruber SMS, Murab S, Mueller K, Ghosh P, Whitlock PW, Lin C-YJ. Decellularized Cartilage Matrix Encapsulated in 3D Printed Scaffolds for Large Osteochondral Repair Promotes Cell Viability and Attachment. ORS 2019 Annual Meeting at the Austin Convention Center in Austin, Texas. February 2-5, 2019 (Poster).
Gruber, S.M.S., Ghosh, P., Whitlock, P. W., Lin, C.Y. (2018, March). Novel Process for 3D Printing with Decellularized Extracellular Matrix for Osteochondral Repair. Poster session presented at annual Orthopedic Research Society annual meeting, New Orleans, Louisiana.
Whitlock P, Gruber S, Mueller K, Ravishankar N, Lin J, Ghosh P. Microspheres Containing Decellularized Cartilage Induce Chondrogenesis In Vitro And Retain Functionality After Incorporation Within A Biocompatible Polymer Filament Useful For Producing A 3D Scaffold. ORS 2018 Annual Meeting at the Hyatt Regency New Orleans in New Orleans, Louisiana, March 10-13, 2018 (Poster).

Publications
Gruber, S.M.S., Murab, S., Ghosh, P., Lin, C-Y., Whitlock, P.W. (2020). In vivo evaluation of a 3-d printed inductive scaffold for the treatment of porcine osteochondral defects. In preparation Biomaterials.
Gruber, S.M.S., Murab, S., Ghosh, P., Whitlock, P.W., Lin, C-Y. (2020). Bioinspired 3D printed scaffolds mimic chondral tissue, prevent hypertrophy, and promote chondral matrix development. In submission Science Advances.
Gruber, S.M.S., Ghosh, P., Mueller, K.W., Whitlock, P.W., Lin, C-Y. (2019). Novel Process for 3D Printing Decellularized Matrices. Journal of Visualized Experiments. https://doi.org/10.3791/58720
Ghosh, P., Gruber, S. M. S., Lin, C.-Y., & Whitlock, P. (2018). Microspheres containing decellularized cartilage induce chondrogenesis in vitro and remain functional after incorporation within a poly(caprolactone) filament useful for fabricating a 3D scaffold. Biofabrication, 10(2). http://doi.org/10.1088/1758-5090/aaa637
Ghosh P, Gruber SM, Lin CJ, Whitlock PW. Chondrogenic potential of decellularized extracellular matrix and their encapsulation in situ. Tissue Engineering Part A. 2016 A22:S114-115.
Gruber SM, Ghosh P, Whitlock PW, Lin CJ. 3D Printing of polylactic acid microspheres in polycaprolactone scaffolds for tissue regeneration. Tissue Engineering Part A. 2016 A22:S44-44.

Further Funding:: 2019-2022 MTF Biologics Extramural Research Grant. “Novel Process for 3D Printing with Decellularized Extracellular Matrix for Tissue Regeneration”. $300,000. PI: James Lin, PhD. Co-PI: Patrick W Whitlock, MD,PhD.