Molecular Genetics of Adolescent Idiopathic Scoliosis
Grant Recipient: Jose Morecuende, MD
- Presentations & Publications:
- Presentations: 1. Morcuende, JA, Minhas, R, Dolan, LA, Stevens, J, Beck, J, Weinstein, SL, Sheffield, V. Melatonin-1A receptor allelic variants in families with Adolescent Idiopathic Scoliosis. Annual meeting of the Pediatric Orthopaedic Surgery of North America, Salt Lake City, Utah, May 2002. 2. Wilkins J, Oji G, Ferguson A, Weinstein SL, Sheffield V, Morcuende JA. Genetic dissection of the melatonin pathway in patients with adolescent idiopathic scoliosis. Annual Meeting Pediatric Orthopaedic Society of North America, St. Louis, MO, April 29-May 1, 2004. 3. Wilkins J, Oji G, Gomez P, Ferguson A, Weinstein SL, Sheffield V, Morcuende JA. Mutation analysis of hMEl-1B, GRP50, and ROR-alpha in patients with familial idiopathic scoliosis. Mid-America Orthopaedic Association, Amelia Island, FL, April 15, 2005. Papers: 1. Morcuende JA, Raman, M, Stevens J, Dolan L, Wang K, Weinstein SL, Sheffield V. Allelic variants of human melatonin 1-A (hMel-1A) in patients with familial adolescent idiopathic scoliosis. Spine, 28(17):2025-2029, 2003. 2. Morcuende JA, Wilkins J, Ferguson A, Sheffield V. Evaluation of melatonin pathway genes in patients with familial idiopathic scoliosis. Am J Hum Genet, submitted.
- Further Funding:
- 1. Gene Mapping for Familial Adolescent Idiopathic Scoliosis (1/1/03-12/31/04), Principal Investigator: Jose A. Morcuende, MD, PhD, Co-Principal Investigators: Val Sheffield, MD, Stuart L Weinstein, MD, Kai Wang, PhD, Funded by: Howard Hughes Medical Institute ($50,000/ 2 years) 2. Genetic Mapping of Familial Idiopathic Scoliosis (6/1/2006-6/30/2009), Principal Investigator: Jose A. Morcuende, MD, PhD, Co-Principal Investigator: Val Sheffield, MD, PhD, Funded by: National Health Institute (NIAMS)- 1 K08 AR053301-01A1 ($361,456)
