Research Award Details

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Role of the Hypoxia Signaling Pathway in Spine Development

Grant Recipient: Frances A. Farley, MD

Co-Investigators: Ernestina Schipani
Regents of the University of Michigan
Presentations & Publications:
Qing Yao, Frances Farley and Ernestina Schipani. Loss of HIF-1α impairs somitogenesis and causes congenital scoliosis. 20th Annual Frederick J. Fischer Pediatric Orthopaedic Lectureship, April 28th, 2017 University of Michigan, Ann Arbor, MI, USA
Loss of Hypoxia-Inducible factor-1α in the presomitic mesoderm impairs somitogenesis and causes spine and rib abnormalities reminiscent of Jarcho-Levin syndrome. Qing Yao, Laura Mangiavini, Jiarui Hu, Matthew J. Anderson, Christophe Merceron, Mohd Parvez Khan, Zachary Tata, Krishna Vemulapalli, Kyriel Pineault, Amato J. Giaccia, Deneen Wellik, Mark Lewandoski, Frances Farley* and Ernestina Schipani* (In preparation) (*Co-senior authors)
Further Funding:
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