Research Award Details

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The Effect ofPamidronate on Bone Healing in the OIM Mouse Model of Osteogenesis Imperfecta (Resubmission)

Grant Recipient: Arabella Leet, MD

Co-Investigators: Neal Fedarko, PhD
Institution:
Johns Hopkins, Baltimore, MD
Presentations & Publications:
Papers in Review: 1. Leet AI, Kazarian T, Sponseller PD, Shapiro JR, Fedarko NS. Altered Energy Metabolism In Osteogenesis Imperfecta Osteoblasts. In Review. 2. Leet AI, Kazarian T, Jain A, McCarthy E, Shapiro JS, Fedarko N. The Paradoxical Response of Human Osteoblasts in Patients with Osteogenesis Imperfecta to Alendronate. In Review. Presentations: 1. Leet AI, Kazarian T, Jain A, McCarthy E, Shapiro JS, Fedarko N. "The Paradoxical Effect of Alendronate on Osteoblasts From Patients With Osteogenesis Imperfecta." 25th Annual Meeting of the European Pediatric Orthopedic Society: Sorrento, Italy, April 13, 2007. 2. Leet AI, Kazarian T, Jain A, McCarthy E, Shapiro JS, Fedarko N. "The Paradoxical Response of Human Osteoblasts in Patients with Osteogenesis Imperfecta to Alendronate". Pediatric Orthopedic Society of North America, Annual Meeting: Hollywood, Florida, May 26, 2007. 3. Leet AI. "Surgical Blood Loss in Patients with Osteogenesis Imperfecta: A Clinical and Translational Study." 4th Annual Clinical OI Meeting, Baltimore, Maryland, October 30, 2008. 4. Leet AI. "Medical Management of Osteogenesis Imperfecta". Pediatric Orthopedic Society of North America, Specialty Day, 2009. American Academy of Orthopedic Surgeons, 76th Annual Meeting: Las Vegas, Nevada, February 28, 2009. 5. Leet AI, Ying N, Jain A, Kazarian T, Fedarko N. "Bisphoshonates Suppress the Initial Inflammatory Response after a Fracture in a Mouse Model of Osteogenesis Imperfecta (OI)". Pediatric Orthopedic Society of North America, Annual Meeting: Boston, Massachusetts, May 1, 2009. 6. Leet AI. "Osteogenesis Imperfecta: New Drugs, New Rods, New Challenges" Orthopedic Grand Rounds. Stanford University. June 23, 2010. 7. Leet AI. Instructional Course: "Osteogenesis Imperfecta" American Academy of Cerebral Palsy and Developmental Medicine. Washington DC, September 25, 2010.
Further Funding:
July 1, 2007 - July 1, 2009-OI. Foundation Michael Geisman Research Fund: "The Effect of Bisphosphonates on Human and Mouse Osteoblasts and Mouse Bone Marrow Stromal Cells." Total direct: $100,000; PI: Arabella I. Leet; 50% effort
Additional Information: