Research Award Details

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Protein Tyrosine Phosphatase Shp2 in Osteoclastogenesis and Bone Remodeling

Grant Recipient: Wentian Yang, MD, PhD

Co-Investigators:
Institution:
Rhode Island Hospital, Providence
Presentations & Publications:
Presentations: 1. 11/20/2013 - Yang, Wentian Invited talk: “Regulation of Ctsk+ chondroid progenitors by the PTPase Shp2”. The 3rd International Conference on Cell Science & Stem Cell Research. Baltimore-BWI, MD, USA 2. 11/17/2012 - Yang, Wentian Invited Talk: “The expanding role for PTPase Shp2 in skeletal development and diseases”. ASBMR-COA session of the 7th International Congress on Orthopaedic Research, Beijing. 3. 11/1/2012 - Yang Wentian invited talk: “Shp2 deficiency in perichondrial groove of Ranvier Cells causes metachondromatosis”. The 4th International MHE Research Conference, Philadelphia. 4. 4/2/2012 - Yang, Wentian Invited talk: “Cellular context-specific tumor suppression by PTPN11 gene,” American Association of Cancer Research Annual Meeting, Chicago. 5. 1/14/2011 - Yang, Wentian Podium presentation: “Shp2 via Erk/Rsk2-mediated feedback signaling regulates M-CSF-evoked PI3 kinase/Akt activation”. 2011 Annual Meeting of the Orthopaedic Research Society, Long Beach/CA. 6. 3/6/2010 - New Orleans the 56th annual ORS Meeting . Podium Presentation “Osteoclast Development and Skeletal Remodeling Require PTPase Shp2 7. 3/25/2010 - Institute of Molecular Medicine, Peking University , Beijing “ Regulation of PI3 Kinase Pathway by Rsk2-Mediated Negative Feedback Signaling” 8. 3/24/2010 - Institute of Basic Medical Science, Peking Union Hospital/Chinese Academy of Medical Science “Shp2 Mutations in Myeloid Proliferative Disorders” 9. 2/6/2010 - Boston Biology and Biotechnology Conference, Brandies University, Boston/MA. Podium Presentation “Regulation of c-Fms Signaling and Osteoclast Development by Shp2” Publications: 1. Wentian Yang (corresponding author), Jianguo Wang, Douglas C. Moore, Haipei Liang, Mark Dooner, Qian Wu, Richard Terek, Qian Chen, Michael G. Ehrlich, Peter J. Quesenberry & Benjamin G. Neel Ptpn11 Deletion in A Novel Cartilage Cell Causes Metachondromatosis by Activating Hedgehog Signaling. Nature 2013; 499, 491–495. doi:10.1038/nature12396 2. Yang W (corresponding author), Neel BG. From an orphan disease to a generalized molecular mechanism: PTPN11 loss-of-function mutations in the pathogenesis of metachondromatosis. Rare Diseases 2013; 1:e26657. 10.4161/rdis.26657. 3. Wentian Yang, Caterina Iorio, Gordon Chan, Sunao Takeshita, Sumin Kang, Jing Chen, Jack Taunton, Peter J. Quesenberry, Benjamin G. Neel. A Rsk2-Mediated Negative Feedback Loop Regulates M-CSF-Evoked PI-3 Kinase/Akt Activation Science (Signaling), 2010 (under review)
Further Funding:
1. NIHR21AR057156 Yang (PI) 10/09-9/11, “Shp2 in Osteoclastogenesis and Bone Remodeling,” The major goal of this project is to understand the biological and biochemical role of Shp2 in osteoclast development and function. 2. NIH/NCRR P20 RR025179 Project III ( PI: Yang. ): Shp2 in Hematopoietic Stem Cell Property Maintenance. The major goal of this project is to understand how Shp2 regulates hematopoietic stem cell self-renewal and multilineage differentiation.
Additional Information: