Research Award Details

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Grant Recipient: James Aronson, MD

Co-Investigators:
Institution:
Arkansas Childrens Hospital, Little Rock
Presentations & Publications:
Published articles: 1. Aronson, J., Shen, X.C., Skinner, R.A., Hogue, W.R., Badger, T.M. and Lumpkin, C. Jr., “Rat Model of Distraction Osteogenesis,” Journal of Orthopaedic Research, V.15, pp.221-226, 1997. 2. Aronson, J., Shen, X.D., Gao, G.G., Quattlebaum, Miller T., Skinner, R.A., Badger, T.M., Lumpkin, C.K., “Sustained Proliferation Accompanies Distraction Osteogenesis in the Rat”, Journal of Orthopaedic Research, V.15, pp.563-569, 1997. 3. Aronson, J., et al.,"Development of Tensile Strength during Distraction Osteogenesis in a Rat Model,” Journal of Orthopaedic Research V.19, pp.64-69, 2001. 4. Aronson, J., et al., "The Effect of Aging on Distraction Osteogenesis in the Rat," Journal of Orthopaedic Research, V.19, pp.421-427, 2001. 5. Perrien DS, Brown EC, Aronson J. et al.: “Immunohistochemical Study of Osteopontin Expression during Distraction Osteogenesis in the Rat,” Journal of Histochemistry and Cytochemistry, V.50:N.4, pp.567-574, 2002. 6. Brown EC, Perrien DS, Fletcher TW, Irby DJ, Aronson J. Gao GG, Hogue WR, Skinner RA, Suva LJ, Ronis MJJ, Hakkak R, Badger TM, Lumpkin CK Jr., “ Skeletal Toxicity Associated with Chronic Ethanol Exposure in a Rat Model Utilizing Total Enteral Nutrition.,” J Pharmacol Exp Ther V.301, pp.1132-1138, 2002. 7. Perrien D, Brown E., Fletcher T., Irby J., Aronson J., Gao G., Skinner R., Hogue W., Feige W., Suva L., Ronis M., Badger T., and Lumpkin CK Jr., “ Interleukin-1 and Tumor Necrosis Factor Antagonists Attenuate Ethanol-Induced Inhibition of Bone Formation in a Rat Model of Distraction Osteogenesis,” The Journal of Pharmacology and Experimental Therapeutics,V. 303, pp.904-908, 2002. 8. Brown EC, Perrien DS, Aronson J., Gao GG, Hogue WR, Skinner RA, Suva LJ, Badger TM, Lumpkin CK Jr.,”Il-1 and TNF antagonists attenuate ethanol-induced inhibition of formation in a rat model of fixated fracture healing,” J .Pharmacol Exp Ther, V.303, pp.904-908, 2002. 9. .Brown EC, Perrien DS, Liu Z, Skinner RA, Aronson J., Suva LJ, Lumpkin CK Jr., “Chronic Ethanol Exposure is Associated with Increases in TNF and Inhibition of Proliferation in the Rat Distraction Gap,” Cytokine V.23:N.6, pp.179-89, 2003. 10. Perrien, D.S., Wahl, E.C., Hogue, W.R., Feige, U., Aronson, J., Ronis, M.J.J.R., Badger, T.M., and Lumpkin, C.K., Jr., “IL-1 and TNF Antagonists Prevent Inhibition of Fracture Healing by Ethanol in Rats,” Toxicological Science, e-published October, 2004. 11. Thrailkell KM, Liu L, Wahl EC, Bunn RC, Cockrell GE, Perrien DS, Skinner RA, Fowlkes JF, Aronson J, Lumpkin CK Jr., “Bone Formation is Impaired in a Model of Type 1 Diabetes,” Diabetes, V.54:N.10, pp. 2875-2881, 2005. 12. Wahl EC, Perrein DS, Aronson J., Liu Z, Fletcher TW, Skinner RA, Feige U, Suva LJ, Badger TM, Lumpkin CK Jr.,”Ethanol-induced inhibition of bone formation in a rat model of distraction osteogenesis: a role for the TNF. Signaling axis,” Alcohol Clin Exp Res, V.29, pp.1466-1472, 2005. 13. Shankar K, Hidestrand M, Haley R, Skinner RA, Hogue W, Jo CH, Simpson P, Lumpin CK Jr, Aronson J, Badger TM, Ronis M.J. “Different molecular mechanisms underlie ethanol induced bone loss in cycling and pregnant rats,” Endocrinology. V.147:N., pp. 166-178 Jan., 2006. Awards: 2003 Nicholas Andry Award published by Clinical Orthopaedics and Related Research in an article entitled: “Modulation of Distraction Osteogenesis in the Aged Rat by Fibroblast Growth Factor.” In specific the Huene Award led to the NIH RO3 grant entitled “Modulation of Osteogenesis in Aged Rats using Fibroblast Growth Factor” which spanned from 1997 to 2002. Presentations: 1. “Type II Diabetes and Osteoblastogenesis,” NIDDK/NIH. (2004-06). $285,250. 2. “Ethanol and Osteoblastogenesis,” as an RO1 grant from the National Institute of Alcohol Abuse and Alcoholism. (2005-2010). $1,095,904. 3. “Ethanol effects on Bone Formation in Pregnancy” is an RO1 grant from the National Institute of Alcohol Abuse and Alcoholism (2002-2007). $1,125,000. 4. “Physiology of IGFBP-Degrading Proteinases in Bone” is an RO1 grant from NIH/NIDDK. (1999-2004). $1,250,000. 5. “Growth Hormones Effects on Osteoblast Function,” Pharmacia Endocrine Care International, (2003-04). $44,000. 6. “Aging and Regenerative Osteoblastogenesis: TNF Signaling Axis” from the National Institute of Arthritis and Musculoskeletal and Skin Diseases, (2006-2011). $1,250,000. 7. “Insulin Signaling Axis and Osteoblastogenesis in Type I Diabetes,” NIDDK, (2006-2011). $1,250,000. 8. “Bone Loss with Aging Occurs Due to Increased PPAR-Gamma Activity in Marrow Stem Cells,” NIH/NIA NIAMS RO1 from 2006-2011. $208,000.
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