Research Award Details

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Treatment of Disuse Osteopenia with Bisphosphonates in Growing Bone - Differential Deposition and Healing in Cortical and Cancellous Bone

Grant Recipient: Kenneth Kozloff, PhD

Co-Investigators: Michelle Caird, MD
Institution:
The Regents of the University of Michigan
Presentations & Publications:
Presentations: 1. K.M. Kozloff, J. Foo, S.N. Khan, B.P. Sinder, J. Kreider, M.S. Caird: Hindlimb suspension in young mice as model for pediatric disuse osteopenia, Orthopaedic Research Society Annual Meeting, 2009. 2. K.M. Kozloff, L.I. Volakis, J.C. Marini, M.S. Caird: Validation of fluorescent pamidronate as biomarker for bisphosphonate deposition and retention in vivo, Orthopaedic Research Society Annual Meeting, 2009. 3. M.S. Caird, J. Foo, S.N. Khan, B.P. Sinder, J. Kreider, K.M. Kozloff: Hindlimb suspension in young mice as model for pediatric disuse osteopenia, Pediatric Orthopaedic Society of North America, 2009. 4. K.M. Kozloff, B.P. Sinder, M.S. Caird: Spatial heterogeneity of bisphosphonate delivery and retention influences local healing of bone in model of disuse osteopenia , Orthopaedic Research Society Annual Meeting, 2010. (NIRA winner) 5. M.S. Caird, B.P. Sinder, K.M. Kozloff: Variable delivery and retention of bisphosphonates influence local healing in growing mouse model of pediatric disuse osteopenia, Pediatric Orthopaedic Society of North America, 2010. (Nominated for best basic science paper) 6. K.M. Kozloff, B.P. Sinder, M.S. Caird: Local bisphosphonate heterogeneity revealed by fluorescence imaging is correlated with impaired bone healing in pediatric model of disuse osteoporosis, World Molecular Imaging Conference, Kyoto, 2010. Publications: B.P. Sinder, L.E. White, M. M. Eddy, M.S. Caird, K.M. Kozloff: Spatial heterogeneity of bisphosphonate concentration correlates with local bone healing response in hindlimb suspension, In progress for submission, Summer 2014.
Further Funding:
Treatment of the Growing Spine with Bisphosphonates: Mechanical Properties and Healing, Scoliosis Research Society; (Caird, Michelle Sugiyama PI), Kozloff, Kenneth Michael, Co-I with Effort; 03/2012-02/2013 and Bone Turnover Effects on Bisphosphonate Concentration in the Mandible NIH-NIDCR R21 DE 019812; Kozloff, Kenneth Michael, PI; 04/2011-09/2013.
Additional Information: